Domaines émergents en matière de santé
Le microbiome intestinal est l’écosystème le plus étudié et le mieux caractérisé du corps humain. Cependant, d’autres microbiomes font l’objet d’une attention croissante, notamment le microbiome vaginal, qui est au cœur de notre plateforme dédiée à la santé des femmes, ainsi que les microbiomes de la bouche et de la peau.
La recherche clinique a depuis longtemps démontré les bienfaits des probiotiques pour les affections cutanées telles que la dermatite atopique, principalement grâce à leurs effets immunomodulateurs sur les cellules épithéliales intestinales. Plus récemment, de nouvelles preuves ont mis en évidence l’existence d’un axe microbiote-intestin-peau, qui relie les fonctions remplies par le microbiome intestinal (par exemple, la régulation des réponses immunitaires et de l’inflammation, l’absorption des nutriments) et la santé de la peau.
De même, des études sur le microbiome buccal soulignent le rôle des probiotiques dans la prise en charge des affections caractérisées par une inflammation des gencives, telles que la gingivite et la parodontite. Ces résultats suggèrent des implications plus larges pour l’inflammation systémique et la santé globale, renforçant l’importance des interventions ciblant le microbiome.
Publications choisies
- Blais, L., Auclair-Ouellet, N., Tremblay, A., & Binda, S. (2025). Effect of the Darolac® (Oralis SB®) probiotic formulation on oral health: A narrative review. Microorganisms, 13(2), 408. https://doi.org/10.3390/microorganisms13020408
- Kassem, O., Tremblay, A., Ghaly, M. S. W., Oula, M.-L., Bronner, S., & Binda, S. (2025). A subjective evaluation of the effects of a probiotic formulation on skin quality in young adult females: Open-label proof-of-concept study. International Journal of Probiotics and Prebiotics, 20, 1-9. https://doi.org/10.37290/ijpp2641-7197.20:1-9
- Zhao, W., Ji, L., Li, J., Liu, D., Yan, C., Zhang, C., Wang, X., Liu, Y., & Zheng, S. (2025). Mesaconate from Bacillus subtilis R0179 supernatant attenuates periodontitis by inhibiting Porphyromonas gingivalis in mice. Journal of Periodontal Research, 60, 617-627. https://doi.org/10.1111/jre.13363
- Zhao, W., Ji, L., Li, J., Liu, D., Zhang, C., Wang, X., Liu, Y., & Zheng, S. (2025). Inactivated Bacillus subtilis R0179 inhibits Porphyromonas gingivalis-Induced gingival inflammation via TLR2/NF-κB signaling in a murine model of periodontitis. Inflammation. https://doi.org/10.1007/s10753-025-02348-8
- Zhao, W., Ji, L., Li, J., Liu, D., Zhang, C., Wang, X., Liu, Y., & Zheng, S. (2025). Inactivated Bacillus subtilis R0179 Inhibits Porphyromonas Gingivalis-Induced Gingival Inflammation Via TLR2/NF-κB Signaling in a Murine Model of Periodontitis. Inflammation. https://doi.org/10.1007/s10753-025-02348-8
- Boyapati, R., Peeta, J., Dhulipalla, R., Kolaparthy, L., Adurty, C., & Cheruvu, R. N. S. (2024). Comparative evaluation of the efficacy of probiotic, Aloe vera, povidine-iodine, and chlorhexidine mouthwashes in the treatment of gingival inflammation: A randomized controlled trial. Dental and Medical Problems, 61(2), 181-189. https://doi.org/10.17219/dmp/156425
- Elgun, T., & Merdan, Y. E. (2023). Effect of Motiflor AS probiotic for oral health on cell viability in human gingival fibroblasts and human dental pulp stem cells. Journal of Conservative Dentistry and Endodontics, 26(6), 621-626. https://doi.org/10.4103/jcde.Jcde_125_23
- Nogueira, M. B., Massaut, K. B., Vitola, H. R. S., Siqueira, M. F. F., da Silva, W. P., & Fiorentini Â, M. (2023). Antagonistic activity of Lactobacillus spp. and Bifidobacterium spp. against cariogenic Streptococcus mutans in vitro and viability when added to chewing gum during storage. Brazilian Journal of Microbiology, 54(3), 2197-2204. https://doi.org/10.1007/s42770-023-01021-2
- Gedam, K. Y., & Katre, A. N. (2022). Efficacy of probiotic, chlorhexidine, and sodium fluoride mouthrinses on Mutans Streptococci in 8-to 12-year-old children: A crossover randomized trial. Lifestyle Genomics, 15, 35-44. https://doi.org/10.1159/000519916
- Ranjith, A., Nazimudeen, N. B., & Baiju, K. V. (2022). Probiotic mouthwash as an adjunct to mechanical therapy in the treatment of stage II periodontitis: A randomized controlled clinical trial. International Journal of Dental Hygiene, 20(2), 415-421. https://doi.org/10.1111/idh.12589
- Doppalapudi, R., Vundavalli, S., & Prabhat, M. (2020). Effect of probiotic bacteria on oral Candida in head-and neck-radiotherapy patients: A randomized clinical trial. Journal of Cancer Research and Therapeutics, 16(3), 470-477. https://doi.org/10.4103/jcrt.JCRT_334_18
- Chernyshov, P. V. (2009). B7‐2/CD28 costimulatory pathway in children with atopic dermatitis and its connection with immunoglobulin E, intracellular interleukin‐4 and interferon‐gamma production by T cells during a 1‐month follow‐up. Journal of the European Academy of Dermatology and Venereology, 23(6), 656-659. https://doi.org/10.1111/j.1468-3083.2009.03133.x
- Chernyshov, P. V. (2009). Randomized, placebo-controlled trial on clinical and immunologic effects of probiotic containing Lactobacillus rhamnosus R0011 and L. helveticus R0052 in infants with atopic dermatitis. Microbial Ecology in Health and Disease, 21(3-4), 228-232. https://doi.org/10.3109/08910600903444234