Santé métabolique

Nos recherches sur les bienfaits des probiotiques pour la santé métabolique portent sur des domaines d’intérêt établis de longue date, tels que la gestion de l’obésité, de l’hypercholestérolémie et d’autres facteurs de risque cardiovasculaire, mais aussi sur des domaines nouveaux et émergents, tels que la promotion de la santé musculaire chez les personnes âgées. Nos recherches précliniques, qui utilisent des techniques multiomiques de pointe et bénéficient d’une plateforme Caenorhabditis elegans entièrement intégrée en interne, nous aident à mieux comprendre les mécanismes métaboliques qui sous-tendent les effets de nos probiotiques. Ainsi, nos recherches sur la santé métabolique fournissent de nombreuses informations essentielles à nos recherches dans d’autres domaines de la santé, en plus de mettre en évidence les relations entre les troubles métaboliques et mentaux, et diverses affections dont la prévalence augmente avec le vieillissement.

Ces domaines d’intérêt récents concernent le rôle des probiotiques dans l’atténuation des effets des espèces réactives de l’oxygène, le métabolisme des oligosaccharides du lait maternel chez les nourrissons et la production d’une gamme de métabolites microbiens tels que les acides gras à chaîne courte (AGCC).

Publications choisies

Labarre, A., Guitard, E., Tossing, G., & Parker, J. A. (2025). Suppression of har-1/CHCHD10 phenotypes for ALS-FTD therapy discovery. MicroPublication Biology, 2025. https://doi.org/10.17912/micropub.biology.001598
Zhang, M., Ding, L., Strodl, E., Yin, X., Wen, G., Sun, D., Xian, D., Zhao, Y., Zheng, Y., Liu, F., Hu, R., Zhao, L., Yang, W., & Chen, W. (2025). Early supplement of probiotics reduces the risk of obesity among preschool children: A real-world observational study. Frontiers in Nutrition, 12, 1597894. https://doi.org/10.3389/fnut.2025.1597894
Barry, D. J., Farragher, J. B., Betik, A. C., Fyfe, J. J., Convit, L., & Cooke, M. B. (2024). Investigating the effects of synbiotic supplementation on functional movement, strength and muscle health in older Australians: A study protocol for a double-blind, randomized, placebo-controlled trial. Trials, 25(1). https://doi.org/10.1186/s13063-024-08130-9
Faramia, J., Choi, B. S.-Y., Brunelle, L., Marette, A., Drapeau, V., Tremblay, A., & Picard, F. (2024). Effects of Lacticaseibacillus rhamnosus HA-114 probiotic supplementation on circulating IGFBP-2 levels during a calorie-restricted diet in overweight humans. Journal of Clinical & Translational Endocrinology, 100357. https://doi.org/10.1016/j.jcte.2024.100357
Foster, S. G., Mathew, S., Labarre, A., Parker, J. A., Tompkins, T. A., & Binda, S. (2024). Lacticaseibacillus rhamnosus HA-114 and Bacillus subtilis R0179 Prolong Lifespan and Mitigate Amyloid-β Toxicity in C. elegans via Distinct Mechanisms. Journal of Alzheimer’s Disease, 101(1), 49-60. https://doi.org/10.3233/jad-230948
Guo, C., He, S., Le Barz, M., Binda, S., & Wang, H. (2024). A mix of probiotic strains prevents hepatic steatosis, and improves oxidative stress status and gut microbiota composition in obese mice. Molecular Nutrition & Food Research, 68, 2300672. https://doi.org/10.1002/mnfr.202300672
Noori, M., Shateri, Z., Babajafari, S., Eskandari, M. H., Parastouei, K., Ghasemi, M., Afshari, H., & Samadi, M. (2024). The effect of probiotic-fortified kefir on cardiovascular risk factors in elderly population: A double-blind, randomized, placebo-controlled clinical trial. BMC Nutrition, 10(1), 74. https://doi.org/10.1186/s40795-024-00875-5
Choi, B. S.-Y., et al. (2023). Lacticaseibacillus rhamnosus HA-114 improves eating behaviors and mood-related factors in adults with overweight during weight loss: A randomized controlled trial. Nutritional Neuroscience, 26(7), 667-679. https://doi.org/10.1080/1028415X.2022.2081288
Huang, J., Xu, Y., Wang, M., Yu, S., Li, Y., Tian, H., Zhang, C., & Li, H. (2023). Enterococcus faecium R-026 combined with Bacillus subtilis R-179 alleviate hypercholesterolemia and modulate the gut microbiota in C57BL/6 mice. FEMS Microbiology Letters, 370, 1-10. https://doi.org/10.1093/femsle/fnad118
Myles, E. M., Hamm, S. I., Allden, S. N., Romkey, I. D., O’Leary, M. E., & Perrot, T. S. (2023). A comparative study of Western, high-carbohydrate, and standard lab diet consumption throughout adolescence on metabolic and anxiety-related outcomes in young adult male and female Long-Evans rats. Behavioural Brain Research, 438, 114184. https://doi.org/10.1016/j.bbr.2022.114184
Kim, G., Yoon, Y., Park, J. H., Park, J. W., Noh, M.-g., Kim, H., Park, C., Kwon, H., Park, J.-h., Kim, Y., Sohn, J., Park, S., Kim, H., Im, S.-K., Kim, Y., Chung, H. Y., Nam, M. H., Kwon, J. Y., Kim, I. Y.,…Seong, J. K. (2022). Bifidobacterial carbohydrate/nucleoside metabolism enhances oxidative phosphorylation in white adipose tissue to protect against diet-induced obesity. Microbiome, 10(1), 188. https://doi.org/10.1186/s40168-022-01374-0
Labarre, A., Guitard, E., Tossing, G., Forest, A., Bareke, E., Labrecque, M., Tétreault, M., Ruiz, M., & Parker, J. A. (2022). Fatty acids derived from the probiotic Lacticaseibacillus rhamnosus HA-114 suppress age-dependent neurodegeneration. Communications Biology, 5(1), 1340. https://doi.org/10.1038/s42003-022-04295-8
Huang, J., Huang, J., Yin, T., Lv, H., Zhang, P., & Li, H. (2021). Enterococcus faecium R0026 combined with Bacillus subtilis R0179 prevent obesity-associated hyperlipidemia and modulate gut microbiota in C57BL/6 mice. Journal of Microbiology and Biotechnology, 31(2), 181-188. https://doi.org/10.4014/jmb.2009.09005
Walsh, C., Lane, J. A., Van Sinderen, D., & Hickey, R. M. (2022). Human milk oligosaccharide-sharing by a consortium of infant derived Bifidobacterium species. Scientific Reports, 12(1), 4143. https://doi.org/10.1038/s41598-022-07904-y
Gaisawat, M. B., Iskandar, M. M., MacPherson, C. W., Tompkins, T. A., & Kubow, S. (2019). Probiotic supplementation is associated with increased antioxidant capacity and copper chelation in C. difficile-infected fecal water. Nutrients, 11(9), 2007. https://doi.org/10.3390/nu11092007
Gaisawat, M. B., Macpherson, C. W., Tremblay, J., Piano, A., Iskandar, M. M., Tompkins, T. A., & Kubow, S. (2019). Probiotic supplementation in a Clostridium difficile-infected gastrointestinal model is associated with restoring metabolic function of microbiota. Microorganisms, 8(1), 60. https://doi.org/10.3390/microorganisms8010060
Wang, Q., Lv, L., Jiang, H., Wang, K., Yan, R., Li, Y., Ye, J., Wu, J., Wang, Q., Bian, X., Yang, L., Jiang, X., Xie, J., Lu, Y., Shen, J., & Li, L. (2019). Lactobacillus helveticus R0052 alleviates liver injury by modulating gut microbiome and metabolome in d-galactosamine-treated rats. Applied Microbiology and Biotechnology, 103(23), 9673-9686. https://doi.org/10.1007/s00253-019-10211-8
Xiao, L., Gong, C., Ding, Y., Ding, G., Xu, X., Deng, C., Ze, X., Malard, P., & Ben, X. (2019). Probiotics maintain intestinal secretory immunoglobulin A levels in healthy formula-fed infants: a randomised, double-blind, placebo-controlled study. Beneficial Microbes, 10(7), 729-740. https://doi.org/10.3920/bm2019.0025
De Andrés, J., Manzano, S., García, C., Rodríguez, J., Espinosa-Martos, I., & Jiménez, E. (2018). Modulatory effect of three probiotic strains on infants’ gut microbial composition and immunological parameters on a placebo-controlled, double-blind, randomised study. Beneficial Microbes, 9(4), 573-584. https://doi.org/10.3920/BM2017.0132
Cakir, M., Isbilen, A., Eyupoglu, I., Sag, E., Örem, A., Sen, T., Kaklikkaya, N., & Kaya, G. (2017). Effects of long-term synbiotic supplementation in addition to lifestyle changes in children with obesity-related non-alcoholic fatty liver disease. Turkish Journal of Gastroenterology, 28(5), 377-383. https://doi.org/10.5152/tjg.2017.17084
Manzano, S., De Andrés, J., Castro, I., Rodríguez, J., Jiménez, E., & Espinosa-Martos, I. (2017). Safety and tolerance of three probiotic strains in healthy infants: A multi-centre randomized, double-blind, placebo-controlled trial. Beneficial Microbes, 8(4), 569-578. https://doi.org/10.3920/BM2017.0009
Michalickova, D., Kotur-Stevuljevic, J., Miljkovic, M., Dikic, N., Kostic-Vucicevic, M., Andjelkovic, M., Koricanac, V., & Djordjevic, B. (2018). Effects of probiotic supplementation on selected parameters of blood prooxidant-antioxidant balance in elite athletes: A double-blind randomized placebo-controlled study. Journal of Human Kinetics, 64, 111-122. https://doi.org/10.1515/hukin-2017-0203
Michalickova, D. M., Kostic-Vucicevic, M. M., Vukasinovic-Vesic, M. D., Stojmenovic, T. B., Dikic, N. V., Andjelkovic, M. S., Djordjevic, B. I., Tanaskovic, B. P., & Minic, R. D. (2017). Lactobacillus helveticus Lafti L10 supplementation modulates mucosal and humoral immunity in elite athletes: A randomized, double-blind, placebo-controlled trial. The Journal of Strength & Conditioning Research, 31(1), 62-70. https://doi.org/10.1519/JSC.0000000000001456
Michalickova, D., Minic, R., Dikic, N., Andjelkovic, M., Kostic-Vucicevic, M., Stojmenovic, T., Nikolic, I., & Djordjevic, B. (2016). Lactobacillus helveticus Lafti L10 supplementation reduces respiratory infection duration in a cohort of elite athletes: A randomized, double-blind, placebo-controlled trial. Applied Physiology, Nutrition, and Metabolism, 41(7), 782-789. https://doi.org/10.1139/apnm-2015-0541
Clancy, R. L., Gleeson, M., Cox, A., Callister, R., Dorrington, M., D’Este, C., Pang, G., Pyne, D., Fricker, P., & Henriksson, A. (2006). Reversal in fatigued athletes of a defect in interferon γ secretion after administration of Lactobacillus acidophilus. British Journal of Sports Medicine, 40(4), 351-354. https://doi.org/10.1136/bjsm.2005.024364